(* = co-first author; + = corresponding author)
Bold Names = Glia Engineering Lab members


Trehalose-Guanosine Glycopolymer Hydrogels Direct Adaptive Glia Responses in CNS Injury.

DuBois E.M., Adewumi H.O., O’Connor P. R., Labovitz J. E., & +O’Shea, T.M. 2023. Advanced Materials. (PMID: 37097729). (PubMed)


Lesion environments direct transplanted neural progenitors towards a wound repair astroglial phenotype in mice.

+O’Shea, T.M., Ao, Y., Wang, S., Wollenberg A.L., Kim J.H., Ramos Espinoza, R.A., Czechanski, L.G., Deming, T.J., & +Sofroniew M.V. 2022. Nature Communications. 13. (5702). (Link)

Divergent transcriptional regulation of astrocyte reactivity across disorders.

*Burda, J.E., *O’Shea, T.M., Ao, Y., Suresh, K.B., Wang, S., Bernstein A.M., Chandra, A., Deverasetty, S., Kawaguchi, R., Kim, J.H., McCallum, S., Rogers, A., , Wahane, S., & Sofroniew M.V. 2022. Nature. 606: 557-564. (PubMed)


Foreign body responses in mouse central nervous system mimic natural wound responses and alter biomaterial functions

O’Shea, T.M., Wollenberg, A.L., Kim, J.H., Ao, Y. Deming, T.J. and Sofroniew M.V. 2019. Nature Communications. 11 (6203) (Link)

Injectable diblock copolypeptide hydrogel provides platform to deliver effective concentrations of paclitaxel to an intracranial xenograft model of glioblastoma

Garrett, M.C., O’Shea, T.M., Wollenberg, A.L., Bernstein, A.M., Hung, D., Staarman, B., Soto, H., Deming, T.J., Sofroniew, M.V., and Kornblum, H.I., Plos One. 15(7): e0219632 (PubMed)


Required growth facilitators propel axon regeneration across complete spinal cord injury

*Anderson, M.A., *O’Shea, T.M., Burda, J.E., Ao, Y., Barlatey, S.L., Bernstein A.M., Kim, J.H., James, N.D., Rogers, A., Kato, B., Wollenberg, A.L., Kawaguchi, R., Coppola, G., Wang, C., Deming, T.J., He, Z., Courtine, G., and Sofroniew M.V. Nature. 561: 396–400. (PubMed)

Injectable polypeptide hydrogels via methionine modification for neural stem cell delivery

*Wollenberg, A.L. *O’Shea, T.M., Kim, J., Sofroniew M.V., and Deming, T.J. Biomaterials. 178:527-545. (PubMed)


Conformation directed formation of self-healing diblock copolypeptide hydrogels via polyion complexation

Sun, Y.,Wollenberg, A.L., O’Shea, T.M., Cui, Y., Zhou, Z.H., Sofroniew M.V. and Deming, T.J. . Journal of American Chemical Society. 139(42):15114-15121. (PubMed)

Regulation of peripheral myelination through transcriptional buffering of Egr2 by an antisense long noncoding RNA

Martinez-Moreno, M., O’Shea, T.M., Zepecki, J.P., Olaru, A., Ness, J.K., Langer, R. and Tapinos, N. Cell Reports. 20(8):1950-1963. (PubMed)

Cell biology of spinal cord injury and repair

O’Shea, T.M., Burda, J. E., and Sofroniew M. V. Journal of Clinical Investigation. 127(9):3259-3270. (PubMed)

Smart Materials for Central Nervous System Cell Delivery and Tissue Engineering

O’Shea T.M., Wollenberg A.L., Bernstein A.M., Sarte D.B., Deming T.J., and Sofroniew M.V. . In: Wang Q ed. Smart Materials for Tissue Engineering Applications . Royal Society of Chemistry; 2017. Chapter 19. 529-557. (Link)

Biodegradable scaffolds promote tissue remodeling and functional improvement in non-human primates with acute spinal cord injury

Slotkin, J. R., Pritchard C. D., Luque B., Ye J., Layer R. T., Lawrence M. S., O’Shea T. M., Roy R.R., Zhong H., Vollenweider I., Edgerton V. R., Courtine G., Woodard E. J., and Langer, R. Biomaterials. 123: 63-76. (PubMed)

Ependymal cell contribution to scar formation after spinal cord injury is minimal, local and dependent on direct ependymal injury

Ren, Y., Ao Y., O’Shea T. M., Burda J. E., Bernstein A. M., Brumm A. J., Muthusamy N., Ghashghaei H. T., Carmichael S. T., Cheng L. and Sofroniew M. V. Scientific Reports. 7: 41122. (PubMed)


Astrocyte scar formation aids central nervous system axon regeneration

Anderson M. A., Burda J. E., Ren Y., Ao Y., O’Shea, T.M., Kawaguchi R., Coppola G., Khakh B. S., Deming T. J. and Sofroniew M. V. Nature. 532(7598): 195-200. (PubMed)

Sustained local release of methylprednisolone from a thiol-acrylate poly(ethylene glycol) hydrogel for treating chronic compressive radicular pain

Slotkin J.R., Ness J.K., Snyder K.M., Skiles A.A., Woodard E.J., O’Shea, T.M., Reynolds F.M., Layer R.T., Aimetti A.A., Toms S.A., Langer R., and Tapinos N. Spine . 41(8):E441-8. (PubMed)


Covalent Incorporation of Trehalose within Hydrogels for Enhanced Long-Term Functional Stability and Controlled Release of Biomacromolecules

O’Shea, T.M, Webber, M.J., Aimetti A.A., and Langer R. 2015. Advanced Healthcare Materials. 4(12):1802-12. (PubMed)

Synthesis and Characterization of in situ curing ethoxylated polyol thiol-ene hydrogels for tailorable macromolecule delivery

O’Shea, T.M., Aimetti A.A., Kim E., Yesilyurt V. and Langer R., 2015. Advanced Materials. 27(1). 65-72. (PubMed)


A new model for in vitro testing of novel vitreous substitute candidates
Barth, H., Crafoord S., O’Shea, T.M., Pritchard, C.D., Langer R, Ghosh FK. 2014. Graefe’s Archive for Clinical and Experimental Ophthalmology. 252(10). 1581-1592. (PubMed)

Evaluation of viscoelastic poly(ethylene glycol) sols as vitreous substitutes in an experimental vitrectomy model in rabbits
Pritchard C.D., Crafoord S., Andréasson S., Arnér K.M., O’Shea T.M., Langer R. 2011, Acta Biomaterialia. 7(3):936-943. (PubMed)

A novel injectable thiol-acrylate poly(ethylene glycol) hydrogel for sustained release of methylprednisolone sodium succinate
Pritchard, C.D., O’Shea, T.M., Calo, E., Siegwart, D.J., Anderson, D.G., Langer R., et al. 2011. Biomaterials. 32(2): 587-597. (PubMed)

Preparation and characterization of PLGA-coated porous bioactive glass-ceramic scaffolds for subchondral bone tissue engineering
O’Shea, T.M. & Miao, X. 2009. The Proceeding of the 9th International Symposium on Ceramic Materials and Components for Energy and Environmental Applications, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai. (Link)

Bilayered Scaffolds for Osteochondral Tissue Engineering
O’Shea, T.M. & Miao, X. 2008. Tissue Engineering Part B: Reviews. 14(4): 447-464. (PubMed)

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